GEENIE platform is a proprietary engineered negatively charged protein molecule that deterministically translocates through the cell membrane using a non- endocytic, helical mechanism. It is a non-toxic, low immunogenic carrier platform for therapeutically valuable cargoes.
GEENIE effectively transfers small molecules (e.g. chemotherapeutics), larger biomolecules (e.g. proteins) and small oligonucleotides across the cellular membrane of different cell types.
Key Advantages of GEENIE:
Delivers Functional Biomolecules including proteins and nucleotides.
Universal Carrier for various cell types including primary cells (e.g. stem cells)
Can selectively deliver to intracellular targets (e.g. Nucleus) and specific cell types (e.g. HER2+ expressing cells).
Non-toxic and low immunogenicity
CyGenica’s GEENIE platform is a proprietary engineered negatively charged molecule that works just like a molecular drill boring through the cell membrane to deliver molecular cargoes to the nucleus without causing any harm to the cell, solving the most crucial issue of targeted intracellular delivery. GEENIE can be used to develop in vitro and in vivo delivery mechanisms for drugs, gene editing mechanisms and antibiotics.
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